Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor
نویسندگان
چکیده
منابع مشابه
CHEMOKINES, CYTOKINES, AND INTERLEUKINS Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor
1Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy; 2Unit of Histology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy; 3Department of Biotechnology and Biosciences, University of Milan-Bicocca, Milan, Italy; 4Istituto di Ricerche di Biologia Molecolare P. Angeletti, Pomezia, Rome, Italy...
متن کاملBone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor.
Angiogenesis plays a key role in various physiologic and pathologic conditions, including tumor growth. Drm/gremlin, a member the Dan family of bone morphogenic protein (BMP) antagonists, is commonly thought to affect different processes during growth, differentiation, and development by heterodimerizing various BMPs. Here, we identify Drm/gremlin as a novel proangiogenic factor expressed by en...
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Gremlin is an antagonist of bone morphogenetic protein (BMP) and a major driving force in skeletal modeling in the fetal stage. Several recent reports have shown that Gremlin is also involved in angiogenesis of lung cancer and diabetic retinopathy. The purpose of this study was to investigate the role of Gremlin in tumor angiogenesis in pituitary adenoma. Double fluorescence immunohistochemistr...
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ژورنال
عنوان ژورنال: Blood
سال: 2006
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2006-06-032276